Day :
Keynote Forum
Dr Sergey V. Suchkov
Professor and Chair (full-time job) of the Dept for Personalized Medicine, Precision Nutriology & Biodesign of the Institute for Biotechology & Global Health of the RosBioTech National University, Russia.
Keynote: Personalized and Precision Medicine (PPM) as a Unique Healthcare Model to Be Set Up via Translational Applications and Upgraded Business Modeling to Secure the Human Healthcare, Wellness and Biosafety among Childhood
Time : 11 AM
Biography:
Sergey Suchkov was born in the City of Astrakhan, Russia, in a family of dynasty medical doctors. In 1980, graduated from Astrakhan State Medical University with MD. From 1980 through 1983 has been working as Res Associate, and from 1983 through 1985 as Senior Res Associate at the Inst of Medicical Enzymology, USSR Academy of Medical Sciences. In 1985, maintained his PhD at the Sechenov University. From 1986 through 1989, has been working as Senior Res Associate at the Koltzov Institute of Dev Biology, USSR Academy of Sciences. From 1989 through 1994, was a Director of the Division of Clinical Immunology, Helmholtz Eye Res Institute in Moscow. In 1989-1993, was trained at the NEI, NIH, Bethesda, MD, USA, and Wills Eye Hospital, Philadelphia, PA, USA, as well as at some of the British universities on the invitation of the Royal Society for Immunology. In 1993-1996, was an Executice Secretary-in-Chief of the Editorial Board, Biomedical Science, an int journal published jointly by the USSR Academy of Sciences and the Royal Society of Chemistry, UK. From 1994 through 2006, was a Director (full-time job) of the Division for Clinical Immunology, Vladimiskii Moscow Clinical Research Institute (MONIKI), and The Clinical Immunology Physician-in-Chief (quater-time job) of the Moscow region. In 2002, maintained his Doctor’s Degree at the National Institute of Immunology, Russia. In 1999, was working as a Clinical Immunology Physician (quater-time job) at the “Ehinacea” Clinical Center in Moscow, Russia. From 2006 through 2014, was The First Vice-President (full-time job) of The University of World Politics and Law, Moscow, Russia. From 2000 through 2007, was collaborating with some US and European Healthcare and Pharma companies (half-time job) staying in Moscow, Russia. From 2003 through 2021, was a Professor (quator-time job) of the Dept for Clinical Human Pathology of Sechenov University,Moscow, Russia. From 2007 through 2021, is a Professor (quator-time job) of the Dept for Clinical Allergology & Immunology of A.I. Evdokimov Moscow State University of Medicine & Dentistry, Moscow, Russia. From 2014 through 2021, was a Professor and Director (full-time job) of the Dept (since 2016 The Center) for Personalized & Precision Medicine of Sechenov University,Moscow, Russia. From 2021 through present time, is The President and Physicion-in-Chief, Center for Personalized & Precision Medicine “InMedStar”, Russia From 2021 through 2021, is a Professor and Chair (full-time job) of the Dept for Personalized Medicine, Precision Nutriology & Biodesign of the Institute for Biotechology & Global Health of the RosBioTech National University, Russia.
Abstract:
1. Personalized and Precision Medicine (PPM) as a Unique Healthcare Model to Be Set Up to Secure the Human Healthcare and Pediatric and Reproductive Services.
2. The growing role of Personalized andPrecision Medicine (PPM): finding the right balance between precision medicine and personalized care to drive Personalized & Precision Pediatric Oncology (PPPO) in Clinical Practice.
- Radiation Oncology, Colorectal Cancer and Stem cells, Cancer Causes and Diagnosis, Cancer Biomarkers, Cancer Therapeutics and Novel Approaches , Cancer management and preventions, Gynaecologic Oncology
Session Introduction
Nourhan Abdalkader
School of Pharmacy, Newgiza University, Cairo, Egypt
Title: Measuring the prevalence of fatigue in children with cancer: Evidence from Egypt.
Biography:
Abstract:
Background: Cancer related fatigue (CRF) is a common side effect of cancer and cancer treatment that impacts every aspect of quality of life. To our knowledge, the statistics for prevalence in pediatrics are lacking in Egypt. The aim of this study is to record the prevalence of fatigue and its significant predicting factors in pediatric oncology patients.
Methods: we interviewed children aged 8-18 years with cancer, prescribed chemotherapy and not in severe distress. After the consent of the guardian is taken, the children personally filled 2 fatigue-related questionnaires (PROMIS Pediatric Short Forms of Fatigue (PROMIS fatigue), pedsQL multidimensional fatigue (PedsQL fatigue)) and 3 symptoms related questionnaires.
Results: 42 children (47.6% female) (mean age 12.1 years (SD 3.3 years)) participated. Half of the children were in primary school (n=21, 50%) and most of them had their parents accompanying them (n=35, 83.3%). Most children suffered from a hematological tumor (n=35, 83.3%) and didn’t suffer from other chronic health conditions (n=39, 92.8%). Reported moderate to severe fatigue in children is between half to third of the children depending on the measurement tool used. The mean T-score for PROMIS fatigue was 53.76 (SD 12.5), the mean score for PedsQL fatigue was 74.27 (SD 21.79). Stepwise standardized multivariant linear regression showed that fatigue following PROMIS fatigue could be predicted by depressive symptoms (ðœ·= 0.47, p <0.001) and mobility (ðœ·= -0.39, p =0.002) while following PedsQL fatigue, it could be predicted by upper extremity function (ðœ·= 0.34, p= 0.005), depressive symptoms (ðœ·=-0.49, p <0.001) and treatment status (ðœ·=-0.25, p= 0.013).
Conclusion: CRF is multifactorial and prevalent among children and adolescents with cancer. Moreover, predicting factors differed between different tools as they measure fatigue from different dimensions. PedsQL fatigue was predicted by more factors. There is a need to include fatigue screening for pediatric oncology patients and incorporate its management in the medical care plan.
Dr Vanessa Naguleswaran
Paediatric Registrar, Basildon Hospital, UK
Title: A QI project assessing what proportion of children with neck lumps are having appropriate imaging
Biography:
Dr Vanessa Naguleswaran MBBS MRCPCH is a paediatric registrar ST5 trainee, with an interest in paediatric respiratory. Currently a Health Education England Education fellow, paediatric registrar representative and undertaking PGCert in Medical Education.
Abstract:
Background Suspicious neck lumps/lymphadenopathy is a very common reason for referral to paediatrics and for imaging via neck ultrasounds. Out of the paediatric urgent suspected cancer referrals, 39% are due to suspicious lymphadenopathy; however, literature states that isolated lymphadenopathy is a rare cause of malignancy. Aims • Aim to reduce the number of unnecessary neck ultrasound referrals to paediatric radiology and paediatric outpatient clinic for palpable lymph nodes in the neck • To create guidance when investigation or referrals are required for palpable lymph nodes in the paediatric population Method Collated a list of patients over a seven-month period retrospectively, of children that have had ultrasound neck requested by Basildon Radiology department. Then analyse the data to identify how many requests were rejected, cancelled, and authorised. Check how many reports were suggestive of malignancy. Results Out of 247 requests approximately 31% of Neck USS were cancelled/rejected/DNA. Out of a random sample of 50 patients, 0 patients were suspected malignancy. USS was not useful and did not change the management in 96% of the cases (apart from the one patient that had abscess and one patient who had suspected calculi). Recommendation • Present to ED, Paediatric doctors, GPs, Radiologists and Ultra sonographers. • To create a flowchart that can be disseminated to local GPs. • To check after implementation of the flow chart whether there has been a reduction in the number of unnecessary USS requests over a period.